Corona virus cure found?

doctor with tablet
French researchers use malaria drug to cure 36 patients

Researchers think they've found a cure for corona virus.

French physician-researchers have completed a largely successful clinical trial using a drug originally developed to treal malaria, the New York Post reported.

Hydroxychloroquine, sold under the brand name Plaquenil — and also used to treat arthritis and other ailments — was determined to be effective in killing the deadly bug in laboratory experiments, Forbes reported, citing findings published March 9 in the Clinical Infectious Diseases journal.

The drug developed in 1955 is showing signs that it may also help cure COVID-19 — especially when combined with an antibiotic, a promising new study reveals.

“(W)e predict that the drug has a good potential to combat the disease,” the study’s authors, most from the Chinese Academy of Sciences in Wuhan, wrote in a letter published in Cell Discovery on Wednesday, according to the report.

36 patients — including 20 treated individuals and 16 infected controls — were enrolled in the study, led by Didier Raoult, an infectious disease expert from l’Institut Hospitalo-Universitaire in Marseille.

The treated group was given 600 mg of Plaquenil each day.

The researchers found 50% of the treated group turned from positive to negative for the virus by the 3rd day. By day 6, that figure was up to 70%.

Of the 20 test patients, 6 who were treated with both Plaquenil and the antibiotic azithromycin showed impressive results — with 5 testing negative at day 3. All 6 of them tested negative at day 6.

“Despite its small sample size our survey shows that hydroxychloroquine treatment is significantly associated with viral load reduction/disappearance in COVID-19 patients and its effect is reinforced by azithromycin,” the study concluded. Source: https://www.lexingtonchronicle.com
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France prepares for new coronavirus outbreak with targeted lockdown: PM



PARIS: France was preparing for eventual resurgence of coronavirus epidemic and targeted lockdown would be imposed to preserve economic and social activities, Prime Minister Jean Castex said Wednesday.

"The virus is still here," Castex told local broadcaster BFMTV. "It was time to prepare for a second wave of the epidemic... It is the role of the State to prepare, to anticipate."

"But we would not proceed to a general lockdown like in March, as that has terrible economic and human consequences. Any new lockdown would be targeted," he added.

Castex, who had orchestrated the de-confinement plan, stressed "the need to preserve economic and social life" while implementing emergency measures to contain the epidemic resurgence.

France had put its 67 million residents into lockdown from March 17 to May 11 to curb the spread of the virus. Only necessary journeys were allowed, all non-essential businesses were shut down, factories halted production and borders were closed.

The restrictive rules triggered the country's worst post-war economic recession. The government expected growth to shrink by 11 percent this year and the public budget gap to widen by 11.4 percent.

As of Wednesday, France had registered 29,861 deaths caused by the coronavirus and 165,719 confirmed positive cases. A total of 8,336 infected people remain in hospitals, of whom 582 need life support.Source:https://timesofoman.com/
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Quality issue detected with Flamanville EPR welds

The Flamanville EPR (Image: Alexis Morin and Antoine-Soubigou/EDF)
Quality deviations have been detected on certain welds of the main secondary system in the EPR reactor under construction at Flamanville, northern France, EDF announced today. The utility has informed the French regulator of the discovery, but has yet to determine whether the unit's start-up, expected at the end of this year, will be delayed.

In a pressurised water reactor, steam generators transfer reactor core heat from the primary coolant loop into a secondary loop where it can be used to generate electricity. The secondary loop is a closed system in which steam produced in the steam generator is conducted towards the turbine. Once condensed, the water is returned to the steam generator.

EDF said the first quality deviation in the welding of the main secondary system was detected on 21 March during the initial comprehensive inspection, a regulatory requirement prior to the reactor starting up. This inspection includes an examination of the welds in the primary and secondary systems, and allows an initial reference state of the plant to be established before it begins operating.

Each of the welds had been declared compliant by the consortium of contractors in charge of manufacturing the system, EDF noted.

Following the detection of deviations, EDF decided to carry out additional checks on the 150 welds in question in order to identify exactly which ones are subject to quality deviations. It has also ordered a report into the causes and nature of the deviations, in order to define the necessary corrective actions and methods to be proposed to the French nuclear safety regulator, the Autorité de Sûreté Nucléaire (ASN), so as to meet safety requirements. EDF said it expects to complete the checks and the report by the end of May.

EDF said it today notified the ASN of "a significant event relating to the detection of deviations in the performance checks of the welds".

The part of the main secondary system which directs the steam from the steam generator towards the turbine is already subject to a deviation with respect to the correct application of "high-quality" requirements, EDF noted. This deviation was notified to ASN on 22 February.

"Following the current checks and the licensing process by ASN, EDF will be able to specify whether the project requires an adjustment to its timetable and its costs," EDF said.

Construction work began in December 2007 on the 1650 MWe unit at the Flamanville site in Normandy - where two reactors have been operating since 1986 and 1987. The dome of the reactor building was put in place in July 2013 and the reactor vessel was installed in January 2014. The reactor was originally expected to start commercial operation in 2013, but owing to delays this is now expected late this year.

EDF's roadmap for the Flamanville 3 project, drawn up in September 2015, sees fuel loading and start-up of the reactor at the end of the fourth quarter of 2018. It also sets the project cost at €10.5 billion (at the 2015 rate, excluding interim interest).

Cold functional tests - which verify the leak-tightness of the primary circuit - began at Flamanville 3 on 18 December and were completed on 6 January. Testing of the reactor building to confirm its airtightness was completed on 3 April. Hot functional tests - which involve checking the equipment under similar temperature and pressure conditions to those under which it will operate - are due to start in July.

The first-of-a-kind EPR at Finland's Olkiluoto plant has been under construction since 2005 and has seen several revisions to its start-up date. In October, the schedule for OL3 commencing regular electricity production was again revised from the end of 2018 to May 2019. The unit began functional hot tests in December.

The Taishan 1 EPR in China, which has been under construction since 2009, has completed functional hot tests and will be the first EPR to operate. It is expected to start up later this year, while Taishan 2 is scheduled to begin operating next year.

Researched and written, by World Nuclear News: Source: http://www.world-nuclear-news.org
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